科學研究

學術報告

最新確定的海馬神經回路在學習和記憶中的應用|CIBR Seminar

    |    分享:
2019-09-02

Seminar Type

B-type


Preferred Location

Third Floor Lecture Hall, Jianzan Building (Phase I)

Chinese Institute for Brain Research, Beijing


Time

10:00-11:00  Monday,September 2nd , 2019


Speaker

Xiangmin Xu, Ph.D.

Professor

Department of Anatomy and Neurobiology

School of Medicine

University of California, Irvine


Host

Dr. Fei Zhao


Topic

Illuminating spatial learning and memory neural circuits in health and disease

最新確定的海馬神經回路在學習和記憶中的應用


Abstract

applications of the latest technologies of neuroscience in mapping hippocampal neural circuits related to spatial learning and memory. He will discuss insights from their studies of cortico-hippocampal circuitry associated with subiculum (SUB) projections to CA1.  Specifically, their recent work has identified a distinct sub-population of SUB neurons forming a pathway from visual cortex to CA1 and perirhinal cortex, and demonstrated that this pathway plays a critical role in object-place learning.  These findings in hippocampal circuit mechanisms provide an intriguing new target to counteract Alzheimer's Disease (AD)-related memory impairments.  The Xu lab is currently working to determine whether spatial memory can be rescued by patterned stimulation of the non-canonical subiculum-CA back-projection in AD model mice.

分子遺傳學、病毒學和成像技術的新進展為研究神經環路的結構和功能提供了強大的工具。在這次報告中,徐博士將分享其團隊應用最新技術解析與空間學習記憶相關的海馬神經環路,尤其是與皮層-海馬環路有關的海馬下托(subiculum,SUB)到CA1的投射連接。具體而言,他們最近的工作鑒定出了SUB神經元的一個獨特的亞群可以形成從視覺皮層到CA1及嗅緣皮層 (perirhinal cortex) 的投射,并且證明該環路在物體-空間位置學習中起著關鍵作用。這些海馬環路機制中的新發現為改善阿爾茨海默病(AD)相關的記憶障礙提供了一個新的有力目標。徐博士實驗室目前正在研究是否可以通過刺激非經典SUB-CA神經環路來恢復AD模型小鼠的空間記憶。


Speaker Biography

Education 

08/1998-02/2004      Ph.D., Psychology/Neuroscience, Vanderbilt University

09/1995-06/1998      M.S., Neurobiology, Shanghai Institute of Physiology, Chinese Academy of Sciences

09/1990-06/1995        Bachelor of Medicine, Shanghai Medical University, Shanghai China

Research Statement

I have a strong background in biology, engineering and medicine that I have applied to answering fundamental questions in neuroscience.  My interests focus on neural circuit organization and function, in relation to the neurobiology of sensory perception, learning and memory, and stress.  We use a multidisciplinary approach that combines electrophysiology, photostimulation and optical imaging, molecular genetics and viral tracing.  Our analysis is further refined and informed by engineering and computational techniques.  Our achievements are reflected by our publications in high impact journals, and my receipt of prestigious awards as an independent investigator.  I have been a Principal Investigator for multiple NIH and private foundation grants.  I have active collaborations with many other successful investigators at UC Irvine and at other major research institutions in southern California and elsewhere in the US.